According to The American Cancer Society, Metastatic breast cancer (mBC) is the most serious form of the disease and takes a life in the United States approximately every 12 minutes creating an urgent need for treatment proven to extend life while preserving quality of life. My guests, Dr. Denise A. Yardley, a MONALEESA-2 Investigator, Breast Cancer Research Program, Sarah Cannon Research Institute and Shirley A. Mertz, President, Metastatic Breast Cancer Network, join me with the updated results of a targeted treatment from the Monaleesa-2 trial.